A few tips from ebook+google adsense+SEO tips and tricks :
- Color code your ads to match your web site palette 'exactly'. Instead, in the AdSense code generation interface, make sure you choose the same color as your page background for the ads frame and the ads background.
- Use Google's own AdSense optimization tips and visual heat map to assist you in deciding where on your page to place your AdSense ad code.
- Research competitive keywords using a keyword research tool such as Keyword Discovery or grab a list of the most popular keywords from various sources and use them in your web site pages where relevant.
- Incorporate the AdSense code into your page so that the ads look like a regular part of your site.
- Use Google's new 4 and 5 link ad units wherever possible. They seem to have a much higher Click-Through-Rate (CTR) than regular ad styles.
- Place arrows or images next to your ads to draw attention to them. You can see two different versions on this search engine article library page SearchEngineCollege at the top (where a pointing hand directs your eye to the ads) and the bottom where 3 images draw your attention to each of the three AdSense ads.
- Use the multiple AdSense ads on each of your pages - 3 regular AdSense ads, plus 1 link unit. Use careful placement of these ads so they blend into your site and don't distract from your content.
-Tailor your page content to a particular niche or focus. Page content that is tailored towards a specific theme is more likely to trigger AdWords ads that closely match the content and are therefore more likely to interest your visitors and inspire them to click.
-Use custom Ad Channels for each of your ad placements. For example "Top 5 Link Unit Blue Palette" or "Left Side Navigation Image Skyscraper" etc. Tweak, track and measure the success of each of these custom channels so you know what gives you the highest CTR.